Fibrillar tau alters cerebral endothelial cell metabolism, vascular inflammatory activation, and barrier function in vitro and in vivo.
Guzmán-Hernández R, Fossati S. Alzheimers Dement. 2025 Mar;21(3):e70077. doi: 10.1002/alz.70077. PubMed PMID: 40110691; PubMed Central PMCID: PMC11923556.
High impact publications from the Center.
Fibrillar tau alters cerebral endothelial cell metabolism, vascular inflammatory activation, and barrier function in vitro and in vivo.
Carbonic anhydrase inhibitors prevent presymptomatic capillary flow disturbances in a model of cerebral amyloidosis
Carbonic anhydrase inhibitors prevent presymptomatic capillary flow disturbances in a model of cerebral amyloidosis.
Gutiérrez-Jiménez E, Rasmussen PM, Mikkelsen IK, Kura S, Fruekilde SK, Hansen B, Bordoni L, Carlsen J, Palmfeldt J, Boas DA, Sakadžić S, Vinogradov S, Khatib ME, Ramos-Cejudo J, Wied B, Leduc-Galindo D, Canepa E, Mar AC, Gamallo-Lana B, Fossati S, Østergaard L. Alzheimers Dement. 2025 Mar;21(3):e70023. doi: 10.1002/alz.70023. PubMed PMID: 40133235; PubMed Central PMCID: PMC11936728.
Homocysteine potentiates amyloid β -induced death receptor 4- and 5-mediated cerebral endothelial cell apoptosis, blood brain barrier dysfunction and angiogenic impairment
Homocysteine potentiates amyloid β -induced death receptor 4- and 5-mediated cerebral endothelial cell apoptosis, blood brain barrier dysfunction and angiogenic impairment.
Carey A, Parodi-Rullan R, Vazquez-Torres R, Canepa E, Fossati S. Aging Cell. 2024 May;23(5):e14106. doi: 10.1111/acel.14106. Epub 2024 Feb 15. PubMed PMID: 38358083; PubMed Central PMCID: PMC11113365.
FDA-approved carbonic anhydrase inhibitors reduce amyloid β pathology and improve cognition, by ameliorating cerebrovascular health and glial fitness
FDA-approved carbonic anhydrase inhibitors reduce amyloid β pathology and improve cognition, by ameliorating cerebrovascular health and glial fitness.
Canepa E, Parodi-Rullan R, Vazquez-Torres R, Gamallo-Lana B, Guzman-Hernandez R, Lemon NL, Angiulli F, Debure L, Ilies MA, Østergaard L, Wisniewski T, Gutiérrez-Jiménez E, Mar AC, Fossati S. Alzheimers Dement. 2023 Nov;19(11):5048-5073. doi: 10.1002/alz.13063. Epub 2023 Apr 26. PubMed PMID: 37186121; PubMed Central PMCID: PMC10600328.
Hypertension and hyperhomocysteinemia as modifiable risk factors for Alzheimer's disease and dementia: New evidence, potential therapeutic strategies, and biomarkers
Hypertension and hyperhomocysteinemia as modifiable risk factors for Alzheimer's disease and dementia: New evidence, potential therapeutic strategies, and biomarkers.
Carey A, Fossati S. Alzheimers Dement. 2023 Feb;19(2):671-695. doi: 10.1002/alz.12871. Epub 2022 Nov 19. Review. PubMed PMID: 36401868; PubMed Central PMCID: PMC9931659.
Alzheimer's amyloid β heterogeneous species differentially affect brain endothelial cell viability, blood-brain barrier integrity, and angiogenesis
Alzheimer's amyloid β heterogeneous species differentially affect brain endothelial cell viability, blood-brain barrier integrity, and angiogenesis.
Parodi-Rullán R, Ghiso J, Cabrera E, Rostagno A, Fossati S. Aging Cell. 2020 Nov;19(11):e13258. doi: 10.1111/acel.13258. Epub 2020 Nov 6. PubMed PMID: 33155752; PubMed Central PMCID: PMC7681048.
White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities
White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities.
Alber J, Alladi S, Bae HJ, Barton DA, Beckett LA, Bell JM, Berman SE, Biessels GJ, Black SE, Bos I, Bowman GL, Brai E, Brickman AM, Callahan BL, Corriveau RA, Fossati S, Gottesman RF, Gustafson DR, Hachinski V, Hayden KM, Helman AM, Hughes TM, Isaacs JD, Jefferson AL, Johnson SC, Kapasi A, Kern S, Kwon JC, Kukolja J, Lee A, Lockhart SN, Murray A, Osborn KE, Power MC, Price BR, Rhodius-Meester HFM, Rondeau JA, Rosen AC, Rosene DL, Schneider JA, Scholtzova H, Shaaban CE, Silva NCBS, Snyder HM, Swardfager W, Troen AM, van Veluw SJ, Vemuri P, Wallin A, Wellington C, Wilcock DM, Xie SX, Hainsworth AH. Alzheimers Dement (N Y). 2019;5:107-117. doi: 10.1016/j.trci.2019.02.001. eCollection 2019. Review. PubMed PMID: 31011621; PubMed Central PMCID: PMC6461571.
Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer's Disease.
Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer's Disease.
Parodi-Rullán R, Sone JY, Fossati S. J Alzheimers Dis. 2019;72(4):1019-1039. doi: 10.3233/JAD-190357. Review. PubMed PMID: 31306129; PubMed Central PMCID: PMC6917858.
Traumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link.
Traumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link
Ramos-Cejudo J, Wisniewski T, Marmar C, Zetterberg H, Blennow K, de Leon MJ, Fossati S. . EBioMedicine. 2018 Feb;28:21-30. doi: 10.1016/j.ebiom.2018.01.021. Epub 2018 Jan 31. Review. PubMed PMID: 29396300; PubMed Central PMCID: PMC5835563.
Carbonic anhydrase inhibition selectively prevents amyloid β neurovascular mitochondrial toxicity.
Carbonic anhydrase inhibition selectively prevents amyloid β neurovascular mitochondrial toxicity.
Solesio ME, Peixoto PM, Debure L, Madamba SM, de Leon MJ, Wisniewski T, Pavlov EV, Fossati S. Aging Cell. 2018 Aug;17(4):e12787. doi: 10.1111/acel.12787. Epub 2018 Jun 5. PubMed PMID: 29873184; PubMed Central PMCID: PMC6052473.
5-HT1A Receptors on Dentate Gyrus Granule Cells Confer Stress Resilience.
5-HT1A Receptors on Dentate Gyrus Granule Cells Confer Stress Resilience.
Bickle JG, Li Y, Millette A, Dixon R, Wu S, Arias EC, Luna VM, Anacker C.Biol Psychiatry. 2024 Apr 15;95(8):800-809. doi: 10.1016/j.biopsych.2023.10.007. Epub 2023 Oct 18.PMID: 37863245
Fluoroethylnormemantine, a Novel NMDA Receptor Antagonist, for the Prevention and Treatment of Stress-Induced Maladaptive Behavior.
Fluoroethylnormemantine, a Novel NMDA Receptor Antagonist, for the Prevention and Treatment of Stress-Induced Maladaptive Behavior.
Chen BK, Luna VM, Shannon ME, Hunsberger HC, Mastrodonato A, Stackmann M, McGowan JC, Rubinstenn G, Denny CA.Biol Psychiatry. 2021 Oct 1;90(7):458-472. doi: 10.1016/j.biopsych.2021.04.024. Epub 2021 May 9.PMID: 34274107
Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus.
Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus.
Luna VM, Anacker C, Burghardt NS, Khandaker H, Andreu V, Millette A, Leary P, Ravenelle R, Jimenez JC, Mastrodonato A, Denny CA, Fenton AA, Scharfman HE, Hen R.Science. 2019 May 10;364(6440):578-583. doi: 10.1126/science.aat8789. Epub 2019 May 9.PMID: 31073064
Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus.
Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus.Anacker C, Luna VM, Stevens GS, Millette A, Shores R, Jimenez JC, Chen B, Hen R.Nature. 2018 Jul;559(7712):98-102. doi: 10.1038/s41586-018-0262-4. Epub 2018 Jun 27.PMID: 29950730
Anxiety Cells in a Hippocampal-Hypothalamic Circuit.
Anxiety Cells in a Hippocampal-Hypothalamic Circuit.
Jimenez JC, Su K, Goldberg AR, Luna VM, Biane JS, Ordek G, Zhou P, Ong SK, Wright MA, Zweifel L, Paninski L, Hen R, Kheirbek MA.Neuron. 2018 Feb 7;97(3):670-683.e6. doi: 10.1016/j.neuron.2018.01.016. Epub 2018 Jan 31.PMID: 29397273
Asymmetric rostro-caudal inhibition in the primary olfactory cortex.
Asymmetric rostro-caudal inhibition in the primary olfactory cortex.
Luna VM, Pettit DL.Nat Neurosci. 2010 May;13(5):533-5. doi: 10.1038/nn.2524. Epub 2010 Mar 28.PMID: 20348915
Very low levels of ABCA7 in the cerebrum and Alzheimer's disease onset between the ages of 60 and 80 independently of APOE.
Very low levels of ABCA7 in the cerebrum and Alzheimer's disease onset between the ages of 60 and 80 independently of APOE.
Garliyev V, Lyssenko CA, Wiener JP, Praticò D, Lyssenko NN. J Neuropathol Exp Neurol. 2024 Oct 1;83(10):808-821. doi: 10.1093/jnen/nlae060. PubMed PMID: 38900184; PubMed Central PMCID: PMC11413437.
Down-Regulation of ABCA7 in Human Microglia, Astrocyte and THP-1 Cell Lines by Cholesterol Depletion, IL-1β and TNFα, or PMA. Cells.
Down-Regulation of ABCA7 in Human Microglia, Astrocyte and THP-1 Cell Lines by Cholesterol Depletion, IL-1β and TNFα, or PMA Cells.
Wiener JP, Desire S, Garliyev V, Lyssenko Iii N, Praticò D, Lyssenko NN. 2023 Aug 25;12(17). doi: 10.3390/cells12172143. PubMed PMID: 37681876; PubMed Central PMCID: PMC10486366.
ApoJ/Clusterin concentrations are determinants of cerebrospinal fluid cholesterol efflux capacity and reduced levels are associated with Alzheimer's disease.
ApoJ/Clusterin concentrations are determinants of cerebrospinal fluid cholesterol efflux capacity and reduced levels are associated with Alzheimer's disease.
Ko YA, Billheimer JT, Lyssenko NN, Kueider-Paisley A, Wolk DA, Arnold SE, Leung YY, Shaw LM, Trojanowski JQ, Kaddurah-Daouk RF, Kling MA, Rader DJ. Alzheimers Res Ther. 2022 Dec 26;14(1):194. doi: 10.1186/s13195-022-01119-z. PubMed PMID: 36572909; PubMed Central PMCID: PMC9791777.
The Alzheimer's disease GWAS risk alleles in the ABCA7 promoter and 5' region reduce ABCA7 expression.
The Alzheimer's disease GWAS risk alleles in the ABCA7 promoter and 5' region reduce ABCA7 expression.
Lyssenko NN, Shi X, Praticò D. Acta Neuropathol. 2022 Sep;144(3):585-587. doi: 10.1007/s00401-022-02459-8. Epub 2022 Jun 27. PubMed PMID: 35759012; PubMed Central PMCID: PMC9388598.