Neural tube defects induce abnormal astrocyte development by activation and epigenetic permissiveness of STAT3.
Janik K, Jin LQ, Kyzy KZ, Kaminski R, Smith GM, Krynska B. Exp Neurol. 2025 Mar 30;389:115231. doi: 10.1016/j.expneurol.2025.115231. PubMed PMID: 40169106; NIHMSID:NIHMS2071766.
High impact publications from the Center.
Neural tube defects induce abnormal astrocyte development by activation and epigenetic permissiveness of STAT3
Compensatory adaptation of parallel motor pathways promotes skilled forelimb recovery after spinal cord injury.
Compensatory adaptation of parallel motor pathways promotes skilled forelimb recovery after spinal cord injury.
Sheikh IS, Keefe KM, Sterling NA, Junker IP, Li C, Chen J, Xu XM, Kirby LG, Smith GM. iScience. 2024 Nov 13;27(12):111371. doi: 10.1016/j.isci.2024.111371. eCollection 2024 Dec 20.PMID: 39654633
Fetal Brain-Derived Exosomal miRNAs from Maternal Blood: Potential Diagnostic Biomarkers for Fetal Alcohol Spectrum Disorders
Fetal Brain-Derived Exosomal miRNAs from Maternal Blood: Potential Diagnostic Biomarkers for Fetal Alcohol Spectrum Disorders
Darbinian, N., Hampe, M., Martirosyan, D., Bajwa, A., Darbinyan, A., Merabova, N., Tatevosian, G., Goetzl, L., Amini, S., & Selzer, M. E. (2024). (FASDs). International journal of molecular sciences, 25(11), 5826. https://doi.org/10.3390/ijms25115826
Inhibiting acute, axonal DLK palmitoylation is neuroprotective and avoids deleterious effects of cell-wide DLK inhibition.
Inhibiting acute, axonal DLK palmitoylation is neuroprotective and avoids deleterious effects of cell-wide DLK inhibition
Zhang X, Jeong HK, Niu J, Holland SM, Rotanz BN, Gordon J, Einarson M, Childers W, Thomas GM. Nat. Comms. 2024, in press. [Preprint] Available from https://www.biorxiv.org/content/10.1101/2024.04.19.590310v1
Micro-Scale Control of Oligodendrocyte Morphology and Myelination by the Intellectual Disability-Linked Protein Acyltransferase ZDHHC9.
Micro-Scale Control of Oligodendrocyte Morphology and Myelination by the Intellectual Disability-Linked Protein Acyltransferase ZDHHC9.
Jeong HK, Gonzalez-Fernadez E, Crawley I, Coakley JM, Hwang J, Martin DDO, Bamji SX, Kim JI, Kang SH, Thomas GM. Micro-Scale Control of Oligodendrocyte Morphology and Myelination by the Intellectual Disability-Linked Protein Acyltransferase ZDHHC9. [Preprint] August 27, 2024. eLife peer-reviewed pre-print, available from: https://elifesciences.org/reviewed-preprints/97151
TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves.
TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves. Grove M, Kim H, Pang S, Amaya JP, Hu G, Zhou J, Lemay M, Son YJ. Elife. 2024 Mar 8;13:e87394. doi: 10.7554/eLife.87394.PMID: 38456457
Actin cytoskeletal dynamics do not impose an energy drain on growth cone bioenergetics.
Actin cytoskeletal dynamics do not impose an energy drain on growth cone bioenergetics.
Holland SM, Gallo G. Actin cytoskeletal dynamics do not impose an energy drain on growth cone bioenergetics. J Cell Sci. 2023;136(16):jcs261356. doi: 10.1242/jcs.261356. PubMed PMID: 37534394; PMCID: PMC10445737
An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis -PubMed.
An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis -PubMed.
Sterling NA, Park JY, Park R, Cho SH, Kim S. An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis. Nat Commun. 2023 Jan 5;14(1):82. doi: 10.1038/s41467-022-35719-y. PubMed PMID: 36604424; PMCID: PMC9816111
Identification of Neurocan and Phosphacan as Early Biomarkers for Open Neural Tube Defects.
Identification of Neurocan and Phosphacan as Early Biomarkers for Open Neural Tube Defects.
Janik K, Smith GM, Krynska B. Identification of Neurocan and Phosphacan as Early Biomarkers for Open Neural Tube Defects. Cells. 2023 Apr 4;12(7). doi: 10.3390/cells12071084. PubMed PMID: 37048157; PubMed Central PMCID: PMC10093370.
Oligodendrocyte precursor cells stop sensory axons regenerating into the spinal cord.
Oligodendrocyte precursor cells stop sensory axons regenerating into the spinal cord.
Kim H, Skuba A, Xia J, Han SB, Zhai J, Hu H, Kang SH, Son YJ. Cell Rep. 2023 Sep 26;42(9):113068. doi: 10.1016/j.celrep.2023.113068. Epub 2023 Aug 31.PMID: 37656624
P53 independent pathogenic mechanisms contribute to BubR1 microcephaly -PubMed
P53 independent pathogenic mechanisms contribute to BubR1 microcephaly -PubMed.
Sterling NA, Terry BK, McDonnell JM, Kim S. P53 independent pathogenic mechanisms contribute to BubR1 microcephaly. Front Cell Dev Biol. 2023 Oct 12;11:1282182. doi: 10.3389/fcell.2023.1282182. PubMed PMID: 37900274; PMCID: PMC10602889
Abnormal activation of Yap/Taz contributes to the pathogenesis of tuberous sclerosis complex-PubMed
Abnormal activation of Yap/Taz contributes to the pathogenesis of tuberous sclerosis complex-PubMed.
Terry BK, Park R, Cho SH, Crino PB, Kim S. Abnormal activation of Yap/Taz contributes to the pathogenesis of tuberous sclerosis complex. Hum Mol Genet. 2022 Jun 22;31(12):1979-1996. doi: 10.1093/hmg/ddab374. PubMed PMID: 34999833; PMCID: PMC9239747
Age and Alzheimer's Disease-Related Oligodendrocyte Changes in Hippocampal Subregions.
Age and Alzheimer's Disease-Related Oligodendrocyte Changes in Hippocampal Subregions
DeFlitch L, Gonzalez-Fernandez E, Crawley I, Kang SH. Front Cell Neurosci. 2022;16:847097. doi: 10.3389/fncel.2022.847097. eCollection 2022. PubMed PMID: 35465615; PubMed Central PMCID: PMC9023310.
Viral expression of constitutively active AKT3 induces CST axonal sprouting and regeneration, but also promotes seizures.
Viral expression of constitutively active AKT3 induces CST axonal sprouting and regeneration, but also promotes seizures.
Campion TJ 3rd, Sheikh IS, Smit RD, Iffland PH 2nd, Chen J, Junker IP, Krynska B, Crino PB, Smith GM. Exp Neurol. 2022 Mar;349:113961. doi: 10.1016/j.expneurol.2021.113961. Epub 2021 Dec 23.PMID: 34953897
The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation – PubMed
The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation – PubMed Li F, Lo TY, Miles L, Wang Q, Noristani HN, Li D, Niu J, Trombley S, Goldshteyn JI, Wang C, Wang S, Qiu J, Pogoda K, Mandal K, Brewster M, Rompolas P, He Y, Janmey PA, Thomas GM, Li S, Song Y. The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation. Nat Commun. 2021 Jun 22;12(1):3845. doi: 10.1038/s41467-021-24131-7. PMID: 34158506. PMCID: PMC8219705.
The Axonal Glycolytic Pathway Contributes to Sensory Axon Extension and Growth Cone Dynamics.
The Axonal Glycolytic Pathway Contributes to Sensory Axon Extension and Growth Cone Dynamics
Ketschek A, Sainath R, Holland S, Gallo G. J The Axonal Glycolytic Pathway Contributes to Sensory Axon Extension and Growth Cone Dynamics. Neurosci. 2021;41(31):6637-6651. doi: 10.1523/JNEUROSCI.0321-21.2021. PubMed PMID: 34252036 PMCID: PMC8336710
Bioenergetic Requirements and Spatiotemporal Profile of Nerve Growth Factor Induced PI3K-Akt Signaling Along Sensory Axons.
Bioenergetic Requirements and Spatiotemporal Profile of Nerve Growth Factor Induced PI3K-Akt Signaling Along Sensory Axons
Sainath R, Gallo G. Bioenergetic Requirements and Spatiotemporal Profile of Nerve Growth Factor Induced PI3K-Akt Signaling Along Sensory Axons. Front Mol Neurosci. 2021;14:726331. doi: 10.3389/fnmol.2021.726331. PubMed PMID: 34630035 PMCID: PMC8497901
Ethanol-mediated alterations in oligodendrocyte differentiation in the developing brain.
Ethanol-mediated alterations in oligodendrocyte differentiation in the developing brain. Neurobiology of disease. Darbinian, N., Darbinyan, A., Merabova, N., Bajwa, A., Tatevosian, G., Martirosyan, D., Zhao, H., Selzer, M. E., & Goetzl, L. (2021)., 148, 105181. https://doi.org/10.1016/j.nbd.2020.105181
GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration.
GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration.
Khawaja RR, Agarwal A, Fukaya M, Jeong HK, Gross S, Gonzalez-Fernandez E, Soboloff J, Bergles DE, Kang SH. Cell Rep. 2021 May 18;35(7):109147. doi: 10.1016/j.celrep.2021.109147. PubMed PMID: 34010640; PubMed Central PMCID: PMC8185898. https://pmc.ncbi.nlm.nih.gov/articles/PMC8185898/
Glial metabolic rewiring promotes axon regeneration and functional recovery in the central nervous system – PubMed
Glial metabolic rewiring promotes axon regeneration and functional recovery in the central nervous system – PubMed
Li F, Sami A, Noristani HN, Slattery K, Qiu J1, Groves T, Wang S, Veerasammy K, Chen YX, Morales J, Haynes P, Sehgal A, He Y, Li S*, Song Y*. Glial metabolic rewiring promotes axon regeneration and functional recovery in the central nervous system. Cell Metab. 2020 Nov 3;32(5):767-785.e7. doi: 10.1016/j.cmet.2020.08.015. PMID: 32941799. PMCID: PMC7642184 (*Corresponding authors).
Upregulating Lin28a Promotes Axon Regeneration in Adult Mice with Optic Nerve and Spinal Cord Injury – PubMed
Upregulating Lin28a Promotes Axon Regeneration in Adult Mice with Optic Nerve and Spinal Cord Injury – PubMed Nathan FM, Ohtake Y, Wang S, Jiang X, Sami A, Guo H, Zhou FQ, Li S. Upregulating Lin28a Promotes Axon Regeneration in Adult Mice with Optic Nerve and Spinal Cord Injury. Mol Ther. 2020 Aug 5;28(8):1902-1917. doi: 10.1016/j.ymthe.2020.04.010. PMID: 32353321. PMCID: PMC7403348.