PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks.
Vekariya U, Minakhin L, Chandramouly G, Tyagi M, Kent T, Sullivan-Reed K, Atkins J, Ralph D, Nieborowska-Skorska M, Kukuyan AM, Tang HY, Pomerantz RT, Skorski T. Nat Commun. 2024 Jul 11;15(1):5822. doi: 10.1038/s41467-024-50158-7.PMID: 38987289  

Clonal medicine targeting DNA damage response eradicates leukemia.
Toma MM, Karami A, Nieborowska-Skorska M, Chirtala KN, Pepek M, Hadzijusufovic E, Stoklosa T, Valent P, Skorski T. Leukemia. 2024 Mar;38(3):671-675. doi: 10.1038/s41375-024-02138-5. Epub 2024 Jan 16.PMID: 38228681 

FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs.
Wasserman JS, Faezov B, Patel KR, Kurimchak AM, Palacio SM, Glass DJ, Fowle H, McEwan BC, Xu Q, Zhao Z, Cressey L, Johnson N, Duncan JS, Kettenbach AN, Dunbrack RL Jr, Graña X. FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs. Nat Commun. 2024 Jul 10;15(1):5776. doi: 10.1038/s41467-024-50015-7. PMID: 38982062; PMCID: PMC11233601.

Autophagy Contributes to Homeostasis in Esophageal Epithelium Where High Autophagic Vesicle Level Marks Basal Cells With Limited Proliferation and Enhanced Self-Renewal Potential.
Klochkova A, Karami AL, Fuller AD, Parham LR, Panchani SR, Natarajan S, Jackson JL, Mu A, Tan Y, Cai KQ, Klein-Szanto AJ, Muir AB, Tétreault MP, Graña X, Hamilton KE, Whelan KA.  Cell Mol Gastroenterol Hepatol. 2024;18(1):15-40. doi: 10.1016/j.jcmgh.2024.02.018. Epub 2024 Mar 5. PubMed PMID: 38452871; PubMed Central PMCID: PMC11126828. 

Association between gut microbiota and CpG island methylator phenotype in colorectal cancer.
Park PH, Keith K, Calendo G, Jelinek J, Madzo J, Gharaibeh RZ, Ghosh J, Sapienza C, Jobin C, Issa JJ. Association between gut microbiota and CpG island methylator phenotype in colorectal cancer. Gut Microbes. 2024 Jan-Dec;16(1):2363012. doi: 10.1080/19490976.2024.2363012. Epub 2024 Jun 11. PubMed PMID: 38860458; PubMed Central PMCID: PMC11174071. 

Derivation of human primary prostate epithelial cell lines by differentially targeting the CDKN2A locus along with expression of hTERT.
Wasserman JS, Fowle H, Hashmi R, Atar D, Patel KR, Yarmahmoodi A, Macfarlane AW, Tan Y, Cukierman E, Gligorijevic B, Karami A, Whelan KA, Campbell KS, Graña X. Derivation of human primary prostate epithelial cell lines by differentially targeting the CDKN2A locus along with expression of hTERT. Sci Rep. 2024 Sep 2;14(1):20409. doi: 10.1038/s41598-024-71306-5. PMID: 39223207; PMCID: PMC11369182 

Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and Is Associated with Worse Outcomes.
Pongor LS, Schultz CW, Rinaldi L, Wangsa D, Redon CE, Takahashi N, Fialkoff G, Desai P, Zhang Y, Burkett S, Hermoni N, Vilk N, Gutin J, Gergely R, Zhao Y, Nichols S, Vilimas R, Sciuto L, Graham C, Caravaca JM, Turan S, Tsai-Wei S, Rajapakse VN, Kumar R, Upadhyay D, Kumar S, Kim YS, Roper N, Tran B, Hewitt SM, Kleiner DE, Aladjem MI, Friedman N, Hager GL, Pommier Y, Ried T, Thomas A. Cancer Discov. 2023 Apr 3;13(4):928-949. doi: 10.1158/2159-8290.CD-22-0796. PubMed PMID: 36715552; PubMed Central PMCID: PMC10073312. 

DNA polymerase θ protects leukemia cells from metabolically induced DNA damage.
Vekariya U, Toma M, Nieborowska-Skorska M, Le BV, Caron MC, Kukuyan AM, Sullivan-Reed K, Podszywalow-Bartnicka P, Chitrala KN, Atkins J, Drzewiecka M, Feng W, Chan J, Chatla S, Golovine K, Jelinek J, Sliwinski T, Ghosh J, Matlawska-Wasowska K, Chandramouly G, Nejati R, Wasik M, Sykes SM, Piwocka K, Hadzijusufovic E, Valent P, Pomerantz RT, Morton G, Childers W, Zhao H, Paietta EM, Levine RL, Tallman MS, Fernandez HF, Litzow MR, Gupta GP, Masson JY, Skorski T.Blood. 2023 May 11;141(19):2372-2389. doi: 10.1182/blood.2022018428.PMID: 36580665 

ATR inhibition augments the efficacy of lurbinectedin in small-cell lung cancer.
Schultz CW, Zhang Y, Elmeskini R, Zimmermann A, Fu H, Murai Y, Wangsa D, Kumar S, Takahashi N, Atkinson D, Saha LK, Lee CF, Elenbaas B, Desai P, Sebastian R, Sharma AK, Abel M, Schroeder B, Krishnamurthy M, Kumar R, Roper N, Aladjem M, Zenke FT, Ohler ZW, Pommier Y, Thomas A.  EMBO Mol Med. 2023 Aug 7;15(8):e17313. doi: 10.15252/emmm.202217313. Epub 2023 Jul 25. PubMed PMID: 37491889; PubMed Central PMCID: PMC10405061. 

Interferon-gamma signaling promotes melanoma progression and metastasis.
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Suppression of Ca2+ signaling enhances melanoma progression.
Gross S, Hooper R, Tomar D, Armstead AP, Shanas N, Mallu P, Joshi H, Ray S, Chong PL, Astsaturov I, Farma JM, Cai KQ, Chitrala KN, Elrod JW, Zaidi MR, Soboloff J. EMBO J. 2022 Oct 4;41(19):e110046. doi: 10.15252/embj.2021110046. Epub 2022 Aug 30. PMID: 36039850 

Role of Biomarkers in the Management of Acute Myeloid Leukemia.
Small S, Oh TS, Platanias LC.Int J Mol Sci. 2022 Nov 22;23(23):14543. doi: 10.3390/ijms232314543.PMID: 36498870 

Single cell transcriptomic analysis reveals cellular diversity of murine esophageal epithelium.
Kabir MF, Karami AL, Cruz-Acuña R, Klochkova A, Saxena R, Mu A, Murray MG, Cruz J, Fuller AD, Clevenger MH, Chitrala KN, Tan Y, Keith K, Madzo J, Huang H, Jelinek J, Karakasheva T, Hamilton KE, Muir AB, Tétreault MP, Whelan KA.  Nat Commun. 2022 Apr 20;13(1):2167. doi: 10.1038/s41467-022-29747-x. PubMed PMID: 35443762; PubMed Central PMCID

The FDA-Approved Anthelmintic Pyrvinium Pamoate Inhibits Pancreatic Cancer Cells in Nutrient-Depleted Conditions by Targeting the Mitochondria.
Schultz CW, McCarthy GA, Nerwal T, Nevler A, DuHadaway JB, McCoy MD, Jiang W, Brown SZ, Goetz A, Jain A, Calvert VS, Vishwakarma V, Wang D, Preet R, Cassel J, Summer R, Shaghaghi H, Pommier Y, Baechler SA, Pishvaian MJ, Golan T, Yeo CJ, Petricoin EF, Prendergast GC, Salvino J, Singh PK, Dixon DA, Brody JR.  Mol Cancer Ther. 2021 Nov;20(11):2166-2176. doi: 10.1158/1535-7163.MCT-20-0652. Epub 2021 Aug 19. PubMed PMID: 34413127; PubMed Central PMCID: PMC8859979. 

TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors.
Maifrede S, Le BV, Nieborowska-Skorska M, Golovine K, Sullivan-Reed K, Dunuwille WMB, Nacson J, Hulse M, Keith K, Madzo J, Caruso LB, Gazze Z, Lian Z, Padella A, Chitrala KN, Bartholdy BA, Matlawska-Wasowska K, Di Marcantonio D, Simonetti G, Greiner G, Sykes SM, Valent P, Paietta EM, Tallman MS, Fernandez HF, Litzow MR, Minden MD, Huang J, Martinelli G, Vassiliou GS, Tempera I, Piwocka K, Johnson N, Challen GA, Skorski T.Cancer Res. 2021 Oct 1;81(19):5089-5101. doi: 10.1158/0008-5472.CAN-20-3761. Epub 2021 Jul 2.PMID: 34215619 

PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107.
Fowle H, Zhao Z, Xu Q, Wasserman JS, Wang X, Adeyemi M, Feiser F, Kurimchak AN, Atar D, McEwan BC, Kettenbach AN, Page R, Peti W, Dunbrack RL, Graña X. PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107. Elife. 2021;10. Epub 20211018. doi: 10.7554/eLife.63181. PubMed PMID: 34661528; PMCID: PMC8575462. 

HIV-1 Vpr protein impairs lysosome clearance causing SNCA/alpha-synuclein accumulation in neurons.
Santerre M, Arjona SP, Allen CN, Callen S, Buch S, Sawaya BE. Autophagy. 2021 Jul;17(7):1768-1782. doi: 10.1080/15548627.2021.1915641. Epub 2021 Apr 23.PMID: 33890542

Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A- inactivated clear cell ovarian carcinoma
Wu S, Fukumoto T, Lin JH, Nacarelli T, Wang Y, Ong D, Liu H, Fatkhutdinov N, Zundell J, Karakashev SV, Zhou W, Schwartz L, Tang H, Drapkin R, Liu Q, Huntsman D, Kossenkov A, Speicher D, Schug Z, Dang C, Zhang R. Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A- inactivated clear cell ovarian carcinoma. Nat Cancer. 2021 Feb;2(2):189-200. doi: 10.1038/s43018-020-00160-x. PMID: 34085048; PMCID: PMC8168620 

EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition
Karakashev SV, Fukumoto T, Zhao B, Lin J, Wu S, Fatkhutdinov N, Park PH, Semenova G, Jean S, Cadungog M, Borowsky M, Kossenkov A, Liu Q, Zhang R. EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition. Cancer Cell. 2020 Feb 10;37(2):157-167.e6. doi: 10.1016/j.ccell.2019.12.015. PMID: 32004442, PMCID; PMC7155421 

Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia.
Salik B, Yi H, Hassan N, Santiappillai N, Vick B, Connerty P, Duly A, Trahair T, Woo AJ, Beck D, Liu T, Spiekermann K, Jeremias I, Wang J, Kavallaris M, Haber M, Norris MD, Liebermann DA, D'Andrea RJ, Murriel C, Wang JY. Cancer Cell. 2020 Aug 10;38(2):263-278.e6. doi: 10.1016/j.ccell.2020.05.014. Epub 2020 Jun 18.PMID: 32559496