High impact publications from the Center.

TMEM65 regulates and is required for NCLX-dependent mitochondrial calcium efflux

https://www.nature.com/articles/s42255-025-01250-9 
Garbincius JF, Salik O, Cohen HM, Choya-Foces C, Mangold, AS, Makhoul AD, Schmidt AE, Khalil DY, Doolittle JJ, Wilkinson AS, Murray EK, Lazaropoulos MP, Hildebrand AN, Tomar D, Elrod JW. TMEM65 regulates and is required for NCLX-dependent mitochondrial calcium efflux. Nat Metab 7, 714–729 (2025). https://doi.org/10.1038/s42255-025-01250-9

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

https://www.nature.com/articles/nature22082
Luongo T, Lambert JP, Gross P, Nwokedi M, Lombardi AA, Shanmughapriya S, Carpenter AC, Kometzky D, Gao E, van Berlo JH, Tsai EJ, Molkentin JD, Chen X, Madesh M, Houser SR, Elrod JW. The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability. Nature 545, 93–97 (2017). https://doi.org/10.1038/nature22082.

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

https://www.nature.com/articles/s41467-019-11813-6
Jadiya P, Kolmetzky DW, Tomar D, D, Di Meco A, Lombardi AA, Lambert JP, Luongo TS, Ludtmann MH, Pratico D, Elrod JW. Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease. Nat Commun 10, 3885 (2019). https://doi.org/10.1038/s41467-019-11813-6

Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase

https://www.sciencedirect.com/science/article/pii/S1550413124004108
Liu JY, Kuna RS, Pinheiro LV, Nguyen PTT, Welles JE, Drummond JM, Murali N, Sharma PV, Supplee JG, Shiue M, Zhao S, Farria AT,Kumar A, Ruchhoeft ML, Demetriadou C, Kantner DS, Adam Chatoff A, Megill E, Titchenell PM, Snyder NW, Metallo CM, Wellen KE. Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase. Cell Metabolism, Volume 37, Issue 1, 2025, Pages 239-254.e7, ISSN 1550-4131, https://doi.org/10.1016/j.cmet.2024.10.014

Perfluorochemical-facilitated plasminogen activator delivery to the airways: A novel treatment for inhalational smoke-induced acute lung injury

https://onlinelibrary.wiley.com/doi/full/10.1002/ctm2.26
Wolfson MR,  Enkhbaatar P,  Fukuda S, Nelson CL, Williams III RO, Surasarang SH, Sahakijpijarn S, Calendo G, Komissarov AA, Florova G, Sarva K, Idell SI, Shaffer TH. Perfluorochemical-facilitated plasminogen activator delivery to the airways: a novel treatment for inhalational smoke-induced acute lung injury. Clin Transl Med.  2020; 10: 258–274. https://doi.org/10.1002/ctm2.26

Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

https://www.nature.com/articles/s41467-019-11777-7
Garikipati VNS, Verma SK, Cheng Z, Liang D, Truongcao MM, Cimini M, Yue Y, Huang G, Wang C, Bendict C, Tang Y, Mallaredy V, Ibetti J, Grisanti, L., Schumacher, S.M., Gao E, Rajan S, Wilusz JE, Goukassian D, Houser SR, Koch WJ, Kishore R. Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis. Nat Commun 10, 4317 (2019). https://doi.org/10.1038/s41467-019-11777-7

GPC3-mediated metabolic rewiring of diabetic mesenchymal stromal cells enhances their cardioprotective functions via PKM2 activation

https://www.cell.com/iscience/fulltext/S2589-0042(24)02246-6
Joladarashi D, Thej C, Mallaredy V, Magadum A, Cimini M, Gonzalez C, Truongcao M, Nigro JT, Sethi MK, Gibb AA, Benedict C, Koch WJ, Kishore R. GPC3-mediated metabolic rewiring of diabetic mesenchymal stromal cells enhances their cardioprotective functions via PKM2 activation. iScience. 2024 Sep 24;27(10):111021. doi: 10.1016/j.isci.2024.111021. PMID: 39429777; PMCID: PMC11490746.

Podoplanin neutralization improves cardiac remodeling and function after acute myocardial infarction

https://pubmed.ncbi.nlm.nih.gov/31287805/
Cimini M, Garikipati VNS, de Lucia C, Cheng Z, Wang C, Truongcao MM, Lucchese AM, Roy R, Benedict C, Goukassian DA, Koch WJ, Kishore R. Podoplanin neutralization improves cardiac remodeling and function after acute myocardial infarction. JCI Insight. 2019 Jul 9;5(15):e126967. doi: 10.1172/jci.insight.126967. PMID: 31287805; PMCID: PMC6693826.

Adrenergic orchestration of immune cell dynamics in response to cardiac stress

https://www.sciencedirect.com/science/article/abs/pii/S0022282824001597
Nayak TK, Parasania D, Tilley DG. Adrenergic orchestration of immune cell dynamics in response to cardiac stress. J Mol Cell Cardiol. 2024 Nov;196:115-124. doi: 10.1016/j.yjmcc.2024.09.010. Epub 2024 Sep 19. PMID: 39303854; PMCID: PMC12059806.

Nuclear ATP-citrate lyase regulates chromatin-dependent activation and maintenance of the myofibroblast gene program

https://www.nature.com/articles/s44161-024-00502-3
Lazaropoulos MP, Gibb AA, Chapski DJ, Nair AA, Reiter AN, Roy R, Eaton DM, Bedi KC Jr, Margulies KB, Wellen KE, Estarás C, Vondriska TM, Elrod JW. Nuclear ATP-citrate lyase regulates chromatin-dependent activation and maintenance of the myofibroblast gene program. Nat Cardiovasc Res. 2024 Jul;3(7):869-882. doi: 10.1038/s44161-024-00502-3. Epub 2024 Jul 5. PMID: 39196175; PMCID: PMC11358007.

A retinoic acid:YAP1 signaling axis controls atrial lineage commitment

https://www.sciencedirect.com/science/article/pii/S2211124725004589
Abraham E, Volmert B, Roule T, Huang L, Yu J, Williams AE, Cohen HM, Douglas A, Megill E, Morris A, Stronati E, Fueyo R, Zubillaga M, Elrod JW, Akizu N, Aguirre A, Estaras C. A Retinoic Acid:YAP1 signaling axis controls atrial lineage commitment. bioRxiv [Preprint]. 2024 Jul 12:2024.07.11.602981. doi: 10.1101/2024.07.11.602981. Update in: Cell Rep. 2025 May 7;44(5):115687. doi: 10.1016/j.celrep.2025.115687. PMID: 39026825; PMCID: PMC11257518.