We focus on molecular mechanisms of disease with expertise in mitochondrial biology and metabolism. Our mission is to discover new therapies to treat heart disease, fibrosis, and neurodegeneration. Our team utilizes a wide range of techniques, from discovery-based screening to generating mutant animal models.

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Our research examines the effect of repetition and force on musculoskeletal and neural systems (repetitive strain injury). We also examine surgical ways to restore bladder nerves after sacral spinal root injury.

We investigate the important mechanisms and factors in cardiac cell development. We also design stem cell-based strategies to repair the heart.

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Our RNA biology lab uncovers the molecular and genetic mechanisms of cardiovascular diseases. In particular, we examine the role of small nucleolar RNAs (snoRNAs) and other non-coding RNAs in the human heart’s left ventricle. We integrate advanced RNA  biology techniques with in vivo studies using mouse models. We seek to decode the complex regulatory networks that influence heart function and disease progression. 

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We research processes that maintain the electrical and contractile properties of the heart. And we investigate problems in those processes that can lead to heart disease and death. 

The Kishore lab is investigating how and why cardiovascular disease develops and how it responds to treatment. In particular, we are looking for new ways to improve heart repair after myocardial infarction. Our research uses stem cells, exosomes, anti-inflammatory cytokines, noncoding RNAs, and epigenetic modifications. Another major effort is developing stem cell-derived exosomes as a cell-free therapy. Our research investigates how effective this treatment would be and how factors like diabetes, inflammation, age, and gender would influence outcomes. 

Our lab studies how the heart heals after injury, focusing on the complex interactions between immune cells and fibroblasts in the heart. By uncovering key mechanisms, we aim to develop new therapies to improve heart repair after injury. 

Our research goals are to uncover the molecular signaling mechanisms that contribute to vascular dysfunction and large vessel diseases, such as atherosclerosis and aneurysm. 

We explore how stress influences heart cell function and calcium communication in disease. By combining advanced biosensors, super-resolution imaging, and biochemistry with animal models and human tissues, we aim to uncover novel pathways for improving cardiovascular disease treatments. 

We are a highly collaborative analytical chemistry, toxicology, pharmacology and biochemistry group. We specialize in studies of compartmentalization, at both the cellular and physiological level. 

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Our research encompasses tissue development and regenerative medicine, emphasizing the study of lung epithelium and cardiac myocytes in lung and heart development. Our goal is to develop regenerative approaches to lung and heart diseases.  

We focus on on G protein-coupled receptor (GPRC) regulation of cardiac and immune cell function, inflammation, and remodeling during heart failure or following acute cardiac injury.  

Our lab researches atherosclerosis and diabetes. In particular, we are examining the role of LDL retention in arterial walls, which leads to plaque formation and cardiovascular disease. We also investigate: 

• Diabetic dyslipidemia, caused by the liver's impaired clearance of triglyceride-rich lipoproteins. This can increase the risk of cardiovascular disease. 
• Key proteins in the insulin-signaling pathway. 

We are developing innovative strategies for reducing the impact of traumatic lung and brain injury and protecting both immature and mature lungs from environmental or treatment-related injury. A shared focus across these goals is: 

• Developing clinically relevant animal models. 
• Using perfluorochemical liquids in biomedical research. 
• Using biostatistical modeling to identify functional, inflammatory, and structural outcomes after biomechanical injuries.