Research Interests
Our laboratory is studying the molecular and cellular mechanisms controlling brain development to identify the basis of developmental disorders in the CNS, including autism, learning disorders, intractable epilepsy and mental retardation. One of our research focuses is to determine the role of cell polarity established by asymmetric localization of polarity complex proteins in regulation of neural progenitor proliferation and differentiation, neuronal polarity, neuronal migration and synapse formation. We’re utilizing the conditional allele of Pals1, the central component of apical polarity complex, to assess the molecular mechanism underlying the function of polarity complex proteins and their interacting proteins. Genetic ablations of Pals1 in distinct populations at various time points are performed to understand Pals1’s function in a specific developmental context. Furthermore, gene expression profiling studies and genetic interaction experiments with other signaling pathway mutants are also underway to define their relationships. Additionally, we study other animal models showing brain abnormalities, such as hydrocephaly, cerebellar hypoplasia etc. to elucidate the mechanisms underlying CNS development. In vivo manipulations, including in utero electroporation, viral infection and in vitro analyses using a tissue culture system, and biochemical approaches are also applied.
Education, Training & Credentials
- Postdoctoral fellowship, Department of Neurology, BIDMC/Harvard Medical School, 2007
- PhD, Rutgers University/UMDNJ, 2000
- MS, Sogang University, 1992
- BS, Sogang University, 1990
Memberships
- Society of Neuroscience
- Society of Developmental Biology