https://pubmed.ncbi.nlm.nih.gov/39908265/
Lin CR, Hayek H, Simborio H, Karim L, Bahmed K, Bolla S, Marchetti N, Criner GJ, Tian Y, Kosmider B., Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells, Aging Dis. 2025 Jan 24. doi: 10.14336/AD.2024.1175. Online ahead of print. PMID: 39908265
High impact publications from the Center.
Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells
HOXA1 Contributes to Bronchial Epithelial Cell Cycle Progression by Regulating p21/CDKN1A
https://pubmed.ncbi.nlm.nih.gov/40076953/
McCluskey E, Velli SK, Kaminski R, Markward T, Leming H, Yu D, and Sajjan U. HOXA1 Contributes to Bronchial Epithelial Cell Cycle Progression by Regulating p21/CDKN1A. Int J Mol Sci 2025; 26 (5), 2332. PMID: 40076953; PMCID: PMC11899960; DOI: 10.3390/ijms26052332
Role of Homeobox A1 in Airway Epithelial Generation from Human Airway Basal Cells
https://pubmed.ncbi.nlm.nih.gov/40214503/
Mohsen T, Chen N, and Sajjan U. Role of Hoemobox A1 in Airway Epithelial Generation from Human Airway Basal Cells. Cells 2025; 14(7), 549;
Distinct functional neutrophil phenotypes in sepsis patients correlate with disease severity
https://pubmed.ncbi.nlm.nih.gov/38524125/
Liu, D.; Langston, J.C.; Prabhakarpandian, B.; Kiani, M.F. and Kilpatrick, L.E., The critical role of neutrophil-endothelial cell interactions in sepsis: new synergistic approaches employing organ-on-chip, omics, immune cell phenotyping and in silico modeling to identify new therapeutics. Frontiers in Cellular and Infection Microbiology, 2024 Jan 8;13:1274842. doi: 10.3389/fcimb.2023.1274842. PMID: 38259971
The critical role of neutrophil-endothelial cell interactions in sepsis: new synergistic approaches employing organ-on-chip, omics, immune cell phenotyping and in silico modeling to identify new therapeutics
https://pubmed.ncbi.nlm.nih.gov/38259971/
Yang, Q.; Langston, J.C.; Prosniak, R.; Pettigrew, S; Zhao, H.; Perez, E.; Edelmann, H.; Mansoor, N.; Merali, C.; Merali, S.; Marchetti, N.; Prabhakarpandian, B.; Kiani, M.F. and Kilpatrick, L.E., Distinct functional neutrophil phenotypes in sepsis patients correlates with disease severity. Frontiers in Immunology, 2024 Mar 8;15:1341752. j: 10.3389/fimmu.2024.1341752. eCollection 2024. PMID: 38524125 https://pubmed.ncbi.nlm.nih.gov/38259971/
Mitochondrial dysfunction and impaired DNA damage repair through PICT1 dysregulation in alveolar type II cells in emphysema
https://pmc.ncbi.nlm.nih.gov/articles/PMC11583753/
Simborio H, Hayek H, Kosmider B, Elrod JW, Bolla S, Marchetti N, Criner GJ, Bahmed K. Mitochondrial dysfunction and impaired DNA damage repair through PICT1 dysregulation in alveolar type II cells in emphysema. Cell Commun Signal. 2024 Nov 22;22(1):562. doi: 10.1186/s12964-024-01896-0. PMID: 39578839. https://pmc.ncbi.nlm.nih.gov/articles/PMC11583753/
The Regulation of Fatty Acid Synthase by Exosomal miR-143-5p and miR-342-5p in Idiopathic Pulmonary Fibrosis
https://pmc.ncbi.nlm.nih.gov/articles/PMC11478129/
Hayek H, Rehbini O, Kosmider B, Brandt T, Chatila W, Marchetti N, Criner GJ, Bolla S, Kishore R, Bowler RP, Bahmed K. The Regulation of Fatty Acid Synthase by Exosomal miR-143-5p and miR-342-5p in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2024 Apr;70(4):259-282. doi: 10.1165/rcmb.2023-0232OC. PMID: 38117249. https://pmc.ncbi.nlm.nih.gov/articles/PMC11478129/
UL56 Is Essential for Herpes Simplex Virus-1 Virulence In Vivo but Is Dispensable for Induction of Host-Protective Immunity
https://www.mdpi.com/2076-393X/12/8/837
Tongmuang N, Krishnan M, Connor V, Crump C, Jensen LE.UL56 Is Essential for Herpes Simplex Virus-1 Virulence In Vivo but Is Dispensable for Induction of Host-Protective Immunity. Vaccines (Basel). 2024 Jul 25;12(8):837. doi: 10.3390/vaccines12080837.PMID: 39203963 https://www.mdpi.com/2076-393X/12/8/837
Floxed Il1rl2 Locus with mCherry Reporter Element Reveals Distinct Expression Patterns of the IL-36 Receptor in Barrier Tissues
https://www.mdpi.com/2073-4409/13/9/787
Tongmuang N, Cai KQ, An J, Novy M, Jensen LE. Floxed Il1rl2 Locus with mCherry Reporter Element Reveals Distinct Expression Patterns of the IL-36 Receptor in Barrier Tissues. Cells. 2024 May 6;13(9):787. doi: 10.3390/cells13090787.PMID: 38727323 https://www.mdpi.com/2073-4409/13/9/787
Quercetin improves epithelial regeneration from airway basal cells of COPD patients
https://pubmed.ncbi.nlm.nih.gov/38468259/
McCluskey ES, Liu N, Pandey A, Marchetti N, Kelsen SG, Sajjan US Quercetin Improves Airway Epithelial Regeneration from Airway Basal Cells of COPD Patients. Respir Res. 2024 Mar 11;25(1):120. PMID: 38468259; doi: 10.1186/s12931-024-02742-0. https://pubmed.ncbi.nlm.nih.gov/38468259/
Increased Expression of miR146a Dysregulates TLR2-Induced HBD2 in Airway Epithelial Cells from Patients with COPD
https://pubmed.ncbi.nlm.nih.gov/37228294/
Reddy-Vari H, Kim Y, Rajput C and Sajjan U. Increased Expression of miR146a Dysregulates TLR2-Induced HBD2 in Airway Epithelial Cells from Patients with COPD. ERJ Open Res. 2023 May 22;9(3):00694-2022. PMID: 37228294; PMCID: PMC10204848. DOI: 10.1183/23120541.00694-2022. https://pubmed.ncbi.nlm.nih.gov/37228294/
Status of research and development of learning-based approaches in nuclear science and engineering: A review
https://www.sciencedirect.com/science/article/pii/S0029549319305102
Cai KQ, Shellhamer C, Akiyama T, Jensen LE. Pellino1 Restricts Herpes Simplex Virus Infections in the Epidermis and Dissemination to Sebaceous Glands. J Invest Dermatol. 2023 Apr;143(4):639-647.e2. doi: 10.1016/j.jid.2022.09.007. Epub 2022 Oct 8.PMID: 36216205 https://www-sciencedirect-com.libproxy.temple.edu/science/article/pii/S0022202X22019418?via%3Dihub
Age-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection
https://pubmed.ncbi.nlm.nih.gov/36351902/
Chen J, Deng JC, Zemans RL, Bahmed K, Kosmider B, Zhang M, Peters-Golden M, Goldstein DR. Age-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection. Nat Commun. 2022 Nov 9;13(1):6759. doi: 10.1038/s41467-022-34593-y. PMID: 36351902 https://pubmed.ncbi.nlm.nih.gov/36351902/
Molecular Framework of Mouse Endothelial Cell Dysfunction during Inflammation: A Proteomics Approach
https://pubmed.ncbi.nlm.nih.gov/35955534/
Rossi, M.T., Langston, J.C., Singh, N., Merali, C., Yang, Q., Merali, S., Prabhakarpandian, B., Kilpatrick, L.E and Kiani, M.F. Molecular Framework of Mouse Endothelial Cell Dysfunction during Inflammation: A Proteomic Approach. International Journal of Molecular Sciences, 2022 Jul 29;23(15):8399. doi: 10.3390/ijms23158399. PMID: 35955534 https://pubmed.ncbi.nlm.nih.gov/35955534/
Mitochondrial Ribosome Dysfunction in Human Alveolar Type II Cells in Emphysema
https://pmc.ncbi.nlm.nih.gov/articles/PMC9313339/
Karim L, Lin CR, Kosmider B, Criner G, Marchetti N, Bolla S, Bowler R, Bahmed K. Mitochondrial Ribosome Dysfunction in Human Alveolar Type II Cells in Emphysema Biomedicines. 2022 Jun 24;10(7):1497. doi: 10.3390/biomedicines10071497. PMID: 35884802. https://pmc.ncbi.nlm.nih.gov/articles/PMC9313339/
Chronic Exposure to the Combination of Cigarette Smoke and Morphine Decreases CD4+ Regulatory T Cell Numbers by Reprogramming the Treg Cell Transcriptome
https://pubmed.ncbi.nlm.nih.gov/35514978/
Shao Y, Cornwell W, Xu K, Kirchhoff A, Saaoud F, Lu Y, Jiang X, Criner GJ, Wang H, Rogers TJ, Yang X. 2022. Chronic Exposure to the Combination of Cigarette Smoke and Morphine Decreases CD4+ Regulatory T Cell Numbers by Reprogramming the Treg Cell Transcriptome. Front Immunol. 2022, 13:887681. Pubmed doi: 10.3389/fimmu.887681. PMID: 35514978. PMCID: PMC9065607 https://pubmed.ncbi.nlm.gov/35514978
Expression of SARS-CoV-2 Entry Factors in Human Alveolar Type II Cells in Aging and Emphysema
https://pmc.ncbi.nlm.nih.gov/articles/PMC8301390/
Lin CR, Bahmed K, Simborio H, Hayek H, Bolla S, Marchetti N, Criner GJ, Kosmider B., Expression of SARS-CoV-2 Entry Factors in Human Alveolar Type II Cells in Aging and Emphysema. Biomedicines. 2021 Jul 6;9(7):779. doi: 10.3390/biomedicines9070779. PMID: 3435684318. https://pmc.ncbi.nlm.nih.gov/articles/PMC8301390/
The μ-opioid receptor induces miR-21 expression and is ERK/PKCμ-dependent
https://pubmed.ncbi.nlm.nih.gov/33940234/
Chang JK, Cornwell WD, Rogers TJ. The μ-opioid receptor induces miR-21 expression and is ERK/PKCμ-dependent. J Neuroimmunol. 2021, 356:577585. PMID: 33940234 PMCID: PMC8169580/ DOI: 10.1016/j.jneuroim.2021.577585 https://pubmed.ncbi.nlm.gov/33940234
Tobacco smoke and morphine alter peripheral and CNS inflammation following HIV infection in a humanized mouse model
https://pubmed.ncbi.nlm.nih.gov/32814790/
Cornwell WD, Sriram U, Seliga A, Zuluaga-Ramirez V, Gajghate S, Rom S, Winfield M, Heldt NA, Ambrose D, Rogers TJ, Persidsky Y. Tobacco smoke and morphine alter peripheral and CNS inflammation following HIV infection in a humanized mouse model. Sci Rep. 2020, 19;10(1):13977. PMID: 32814790. PMCID: PMC7438518. DOI: 10.1038/s41598-020-70374-7 https://pubmed.ncbi.nlm.gov/32814790.
Protein kinase C-delta inhibition is organ-protective, enhances pathogen clearance, and improves survival in sepsis
https://pubmed.ncbi.nlm.nih.gov/31908004/
Liverani, E., Tursi, S.A., Cornwell, W.D., Mondrinos, M.J., Sun, S., Buttaro, B.A., Wolfson, M.R., Rogers, T.J., Tükel, Ç. and Kilpatrick, L.E. Protein Kinase C-delta Inhibition is Organ-Protective, Enhances Pathogen Clearance and Improves Survival in Sepsis. The FASEB Journal, Feb;34(2):2497-2510. doi: 10.1096/fj.201900897R. Epub 2019 Dec 23. PMID: 31908004 https://pubmed.ncbi.nlm.nih.gov/31908004/