Research Interests
Dr. Shore’s research interests has been on the mechanisms of cellular signaling. One area of signaling they have been studying is protein kinases. These enzymes are responsible for phosphorylation of specific amino acids, serine, threonine and tyrosine, in proteins. The lab has studied the Abl gene family members each of which encode a tyrosine kinase and the role of these proteins in cellular growth, differentiation and transformation. More recently his lab has been investigating a new phoshoprotein, Snp70, which has a very proline rich composition. His lab has found that this protein is a substrate for several kinases including a serine kinase, CKII, and tyrosine kinase, Src. The consequences of these post-translational modifications on function, stability and localization of the Snp70 protein is currently under investigation. In addition to phosphorylation another critical factor in cell signaling is the ability of individual proteins to interact and form larger functional complexes. One interacting domain that Dr. Shore’s lab has been studying is the SH3 domain. This modular domain binds proline-rich tracts in target proteins. The capture and release of proteins by the SH3 domain is a key step in the assembly and regulation of functional complexes. This is an area of investigation where the Snp70 protein has also provided a model, based upon its ability to bind distinct SH3 domain containing proteins.
Education, Training & Credentials
- Drexel University